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KMID : 0360319690040010031
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Journal of Korean Cancer Research Association
1969 Volume.4 No. 1 p.31 ~ p.46
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The Effect of Growth-promoting Tissue Factor(s) on Regenerating Rat Liver
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Lee Sang-Moon
Chin Byong-Ho
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Abstract
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It is claimed that in the various tissues of animals there are factors which promote the growth and proliferation of the tissues and also factors which inhibit the processes, both categories of factors keeping the balance^(1.2.3.4.5.6.7)).
There is a large volume of researches on growth-promoting factors. Several methods have been used for observing the growth-promoting phenomenon. Bucher^(8)), Christensen^(9)), and Wenneker^(10)) removed ´part of the liver of one partner of parabiotic rats and saw that the mitosis in the liver of the intact parabiont ,promoted. Paschis et al^(11)). observed that a certain tumor transplanted into a partially hepatectomized rat grew unusually fast. This suggests that a humoral growth-promoting factor or factors are liberated by or from the regenerating liver. Glinos and Gey^(12)) used the diluted serum of a partially hepatectomized rat in tissue culture and noticed the mitosis in the liver cells being promoted. Friedrich-Freksa and Zaki^(13)) saw that the mitosis in the liver of a normal rat was promoted after a single venous injection of 1-3 ml of the serum of a partially hepatectomized rat. Blomgvist^(14)), McJunkin et al.^(15)) and Teir et al.^(16)) noticed the growth-promoting effect on the liver of a rat following injections of liver homogenates into the peritoneal cavity of the animal. Blomgvist^(14)) said that the most effective growth-promoting factors are obtained from the homogenates of livers of newborn rats or of livers regenerating after partial hepatectomy.
It is not known whether the growth-promoting substances used in the above studies were the same ones, or whether the growth-promoting factor or factors were a single one or multiple ones.
Our department has made various studies using extracts of growth-promoting tissue factors. Chin and Koo.^(17)) observed considerable promotion in the growth of an Ehrlich ascites tumor in a mouse and in the mitosis of a normal animal following the use of growth-promoting factors obtained from various tissue extracts. Chin and Kim^(18)) used growth-promoting factors obtained from regenerating liver tissues and saw the growth of a transplanted animal tumor and the cell proliferation of normal tissues remarkably promoted. Chin and Bae^(19)) proved by liver scanning that growth-promoting factor(s) extracted from various organs accelerated the regeneration of the liver of a rat. In order to elucidate the relation between a regenerating liver and growth-promoting factors in a way different from those mentioned above, we used growth-promoting tissue factors extracted from the livers of young rats, and observed the processes of the mass increase and the cell multiplication in the regenerating livers of partialy hepatectomized rats, in the
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